SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D/A

Under the Securities Exchange Act of 1934*

(Amendment No. 4)

Mazor Robotics Ltd.

(Name of Issuer)

American Depository Shares

Represented by American Depository Receipts

(Each Representing Two Ordinary Shares,

Par Value NIS 0.01 Per Share)

(Title of Class of Securities)

57886P103

(CUSIP Number)

Larry N. Feinberg

c/o Oracle Investment Management, Inc.

200 Greenwich Avenue

Greenwich, CT 06830

(203) 862-7900

(Name, Address and Telephone Number of Person

Authorized to Receive Notices and Communications)

With a copy to:

Jeffrey Hochman, Esq.

Willkie Farr & Gallagher LLP

787 Seventh Avenue

New York, New York 10019

(212) 728-8000

June 24, 2015

(Date of Event which Requires

Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box: ☐

NOTE: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

SCHEDULE 13D/A

CUSIP No. 57886P103				Page 2 of 9

1	NAMES OF REPORTING PERSONS Larry N. Feinberg
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ☐ (b) ☒
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions) PF
5	CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
6	CITIZENSHIP OR PLACE OF ORGANIZATION United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER 50,000*
		8	SHARED VOTING POWER 2,371,201*
		9	SOLE DISPOSITIVE POWER 50,000*
		10	SHARED DISPOSITIVE POWER 2,371,201*
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,421,201*
12	CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ☐
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 11.44%**
14	TYPE OF REPORTING PERSON (See Instructions) IN

* American Depositary Shares, which represent 100,000 and 4,742,402 ordinary shares, respectively, and 4,842,402 ordinary shares in the aggregate.

** Calculated based on 42,315,402 ordinary shares outstanding as of June 25, 2015, according to information furnished by Mazor Robotics Ltd. on June 25, 2015.

SCHEDULE 13D/A

CUSIP No. 57886P103				Page 3 of 9

1	NAMES OF REPORTING PERSONS Oracle Associates, LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ☐ (b) ☒
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions) N/A
5	CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER -0-
		8	SHARED VOTING POWER 2,317,201*
		9	SOLE DISPOSITIVE POWER -0-
		10	SHARED DISPOSITIVE POWER 2,317,201*
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,317,201*
12	CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ☐
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 10.95%**
14	TYPE OF REPORTING PERSON (See Instructions) OO

* American Depositary Shares, which represent 4,634,402 ordinary shares.

** Calculated based on 42,315,402 ordinary shares outstanding as of June 25, 2015, according to information furnished by Mazor Robotics Ltd. on June 25, 2015.

SCHEDULE 13D/A

CUSIP No. 57886P103				Page 4 of 9

1	NAMES OF REPORTING PERSONS Oracle Partners, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ☐ (b) ☒
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions) OO
5	CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER -0-
		8	SHARED VOTING POWER 1,630,248*
		9	SOLE DISPOSITIVE POWER -0-
		10	SHARED DISPOSITIVE POWER 1,630,248*
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,630,248*
12	CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ☐
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 7.71%**
14	TYPE OF REPORTING PERSON (See Instructions) PN

* American Depositary Shares, which represent 3,260,496 ordinary shares.

** Calculated based on 42,315,402 ordinary shares outstanding as of June 25, 2015, according to information furnished by Mazor Robotics Ltd. on June 25, 2015.

SCHEDULE 13D/A

CUSIP No. 57886P103				Page 5 of 9

1	NAMES OF REPORTING PERSONS Oracle Institutional Partners, LP
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ☐ (b) ☒
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions) N/A
5	CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER -0-
		8	SHARED VOTING POWER 268,250*
		9	SOLE DISPOSITIVE POWER -0-
		10	SHARED DISPOSITIVE POWER 268,250*
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 268,250*
12	CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ☐
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 1.27%**
14	TYPE OF REPORTING PERSON (See Instructions) PN

* American Depositary Shares, which represent 536,500 ordinary shares.

** Calculated based on 42,315,402 ordinary shares outstanding as of June 25, 2015, according to information furnished by Mazor Robotics Ltd. on June 25, 2015.

SCHEDULE 13D/A

CUSIP No. 57886P103				Page 6 of 9

1	NAMES OF REPORTING PERSONS Oracle Ten Fund Master, LP
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) ☐ (b) ☒
3	SEC USE ONLY
4	SOURCE OF FUNDS (See Instructions) N/A
5	CHECK IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) ☐
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		7	SOLE VOTING POWER -0-
		8	SHARED VOTING POWER 418,703*
		9	SOLE DISPOSITIVE POWER -0-
		10	SHARED DISPOSITIVE POWER 418,703*
11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 418,703*
12	CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ☐
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 1.98%**
14	TYPE OF REPORTING PERSON (See Instructions) OO

* American Depositary Shares, which represent 837,406 ordinary shares.

** Calculated based on 42,315,402 ordinary shares outstanding as of June 25, 2015, according to information furnished by Mazor Robotics Ltd. on June 25, 2015.

Pursuant to Rule 13d-2 under the Act, this Amendment No. 4 to Schedule 13D (this “Amendment”) amends and supplements the Schedule 13D filed on June 6, 2013 (the “Original Schedule 13D”), as amended on May 5, 2014 (“Amendment No. 1”), October 9, 2014 (“Amendment No. 2”) and December 5, 2014 (“Amendment No. 3” and, collectively with the Original Schedule 13D, Amendment No. 1, Amendment No. 2 and this Amendment, the “Schedule 13D”), and is being filed on behalf of Oracle Partners, L.P., a Delaware limited partnership (“Oracle Partners”), Oracle Institutional Partners, L.P., a Delaware limited partnership (“Oracle Institutional Partners”), Oracle Ten Fund Master, LP, a Cayman Islands exempted company (“Oracle Ten Fund”), Oracle Associates, LLC, a Delaware limited liability company and the general partner of Oracle Partners, Oracle Institutional Partners and Oracle Ten Fund (“Oracle Associates”), and Larry N. Feinberg, the managing member of Oracle Associates and the sole shareholder, director and president of the investment manager to Oracle Ten Fund Master, LP (each of the foregoing, a “Reporting Person” and collectively, the “Reporting Persons”). This Amendment relates to the American Depositary Shares (“American Depositary Shares” or “ADSs”) represented by American Depositary Receipts of ordinary shares, par value NIS 0.01 (the “Ordinary Shares”) of Mazor Robotics Ltd., an Israeli company (the “Company”).

The Reporting Persons are filing this Amendment to report an increase in their beneficial ownership of American Depositary Shares resulting from acquisitions of American Depositary Shares.

All capitalized terms used herein which are not defined herein have the meanings given to such terms in the Schedule 13D.

Item 2.

Identity and Background.

Items 2(a) and (c) are hereby amended and restated in their entirety as follows:

(a) This Schedule 13D is being filed on behalf of (i) Oracle Partners, (ii) Oracle Institutional Partners, (iii) Oracle Associates, (iv) Oracle Ten Fund and (v) Larry N. Feinberg. The agreement among the Reporting Persons to file this Schedule 13D jointly in accordance with Rule 13d-1(k) of the Exchange Act is attached hereto as Exhibit 1.

(c) The principal business of Oracle Partners, Oracle Ten Fund and Oracle Institutional Partners is to invest in securities. The principal business of Oracle Associates is to act as general partner to, and exercise investment discretion over securities held by, Oracle Partners, Oracle Institutional Partners, Oracle Ten Fund and certain other entities. The principal business of Mr. Feinberg is to invest in securities through Oracle Associates and certain other entities.

Item 5.

Interest in Securities of the Issuer.

Items 5(a)-(c) of the Schedule 13D are hereby amended and restated in their entirety as follows:

(a) As of June 24, 2015, Oracle Partners was the direct beneficial owner of 1,630,248 American Depositary Shares, representing 7.71% of the outstanding Ordinary Shares (based on 42,315,402 Ordinary Shares outstanding as of June 25, 2015, as reported by the Company to representatives of the Reporting Persons). As of June 24, 2015, Oracle Institutional Partners was the direct beneficial owner of 268,250 American Depositary Shares, representing 1.27% of the outstanding Ordinary Shares (based on 42,315,402 Ordinary Shares outstanding as of June 25, 2015, as reported by the Company to representatives of the Reporting Persons). As of June 24, 2015, Oracle Associates, due to its relationship with Oracle Partners, Oracle Institutional Partners and Oracle Ten Fund Master, LP, may be deemed to beneficially own 2,317,201 American Depositary Shares, representing 10.95% of the outstanding Ordinary Shares (based on 42,315,402 Ordinary Shares outstanding as of June 25, 2015, as reported by the Company to representatives of the Reporting Persons). Mr. Feinberg, as a direct beneficial owner and due to his respective relationships with the other Reporting Persons, may be deemed to beneficially own 2,371,201 American Depositary Shares, representing 11.21% of the outstanding Ordinary Shares (based on 42,315,402 Ordinary Shares outstanding as of June 25, 2015, as reported by the Company to representatives of the Reporting Persons). The Reporting Persons may be deemed to constitute a “person” or “group” within the meaning of Section 13(d)(3) of the Exchange Act. The filing of this Schedule 13D shall not be construed as an admission of such beneficial ownership or that the Reporting Persons constitute a person or a group.

(b) Each of the Reporting Persons shares the power to vote or to direct the vote and to dispose or to direct the disposition of the American Depositary Shares it may be deemed to beneficially own as described in Item 5(a) above, except for Mr. Feinberg with respect to the 50,000 American Depositary Shares he directly beneficially owns and over which he has the sole power to vote or to direct the vote and to dispose or to direct the disposition.

(c) The Reporting Persons have not effected any transactions in the American Depositary Shares in the last sixty days other than the following transactions:

Transacting Party	Date	Transaction Type	Number of ADSs	Price Per ADS (excluding commissions)
Oracle Ten Fund	4/29/2015	Open Market Purchase	3,386	$13.22
Oracle Ten Fund	4/30/2015	Open Market Purchase	3,000	$13.13
Oracle Ten Fund	5/7/2015	Open Market Purchase	3,500	$11.72
Oracle Ten Fund	5/13/2015	Open Market Purchase	4,812	$11.74
Oracle Ten Fund	5/18/2015	Open Market Purchase	8,737	$11.93
Oracle Ten Fund	5/19/2015	Open Market Purchase	1,403	$12.22
Oracle Ten Fund	6/16/2015	Open Market Purchase	6,006	$12.67
Oracle Ten Fund	6/23/2015	Open Market Purchase	35,000	$13.32
Oracle Ten Fund	6/24/2015	Open Market Purchase	43,474	$13.82

Item 7. Material to be Filed as Exhibits.

1	Joint Filing Agreement, dated June 30, 2015, by and among, Larry N. Feinberg, Oracle Partners, L.P., Oracle Institutional Partners, L.P., Oracle Ten Fund Master, LP and Oracle Associates, LLC.

SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

Dated: June 30, 2015	ORACLE PARTNERS, L.P. By: ORACLE ASSOCIATES, LLC, its general partner By: /s/ Larry N. Feinberg Name: Larry N. Feinberg Title: Managing Member
Dated: June 30, 2015	ORACLE INSTITUTIONAL PARTNERS, L.P. By: ORACLE ASSOCIATES, LLC, its general partner By: /s/ Larry N. Feinberg Name: Larry N. Feinberg Title: Managing Member
Dated: June 30, 2015	ORACLE TEN FUND MASTER, LP By: ORACLE ASSOCIATES, LLC, its general partner By: /s/ Larry N. Feinberg Name: Larry N. Feinberg Title: Managing Member
Dated: June 30, 2015	ORACLE ASSOCIATES, LLC By: /s/ Larry N. Feinberg Name: Larry N. Feinberg Title: Managing Member
Dated: June 30, 2015	LARRY N. FEINBERG By: /s/ Larry N. Feinberg